Two weeks after administration of the booster dose, the median neutralizing antibody titer increased substantially, to 5783 against the WA1/2020 isolate, 900 against the BA.1 subvariant, 829 against the BA.2 subvariant, 410 against the BA.2.12.1 subvariant, and 275 against the BA.4 or BA.5 subvariant. Subscribe. Therefore, antibody immunity acquired by natural infection or different modes of vaccination may have a differing susceptibility to erosion by SARS-CoV-2 evolution., Limited knowledge is available on the relationship between antigen-specific immune responses and COVID-19 disease severity. On Wednesday, HHS announced Dr. Alexander is leaving the department permanently and Mr. Caputo will take a 60-day medical absence. ga('ads.send', { In college I was a double major in English and Political Science, served as Head of our Model United Nations team, and was our school's Rhodes Scholar Candidate. In another, he blasted the agency for reporting on COVID-19 risks to children, contrary to Mr. Trumps call for schools to reopen. let gads_event; A Collection of Interesting, Important, and Controversial Perspectives Largely Excluded from the American Mainstream Media He advocated for colleges to be open with the goal of mass infecting students. Reviewed in the United States on November 30, 2022. The school describes Alexander as an expert on health-research methods. We completed a combined examination of all three branches of adaptive immunity at the level of SARS-CoV-2-specific CD4+and CD8+Tcell and neutralizing antibody responses in acute and convalescent subjects. pg.acq.push(function() { They're taking it away from us folks, and the longer we sleep, the easier it becomes for them. But Susan Emigh, a university spokeswoman, defended the professors right to speak his mind, while stressing that he is not being paid and is not currently teaching at McMaster. Alexander holds master's level study at York University Canada, a master's in epidemiology at the University of Toronto, a master's in evidence-based medicine at Oxford and a doctorate in evidence-based medicine and research methods from McMaster University in Canada. Our results suggest that infection-induced primary MBCs have undergone more affinity maturation than vaccine-induced primary MBCs and produce more robust secondary responses., Optimal immune responses furnish long-lasting (durable) antibodies protective across dynamically mutating viral variants (broad). Well-preserved T cell immunity to Omicron is likely to contribute to protection from severe COVID-19, supporting early clinical observations from South Africa., 69% (54/78) of the epitopes recognized by CD8+T cells are completely invariant. ga('ads.send', { , has expertise in teaching of epidemiology (clinical epidemiology), evidence-based medicine, and research methodology. This is a major concern if the mRNA vaccine is impacting N Ab inducement, for then the unvaccinated who are naturally exposed and infected and mount an immune response, will show a far superior and broad immune response that includes Ab to not only the mutable spike but also to other viral proteins such as the interior nucleocapsid protein (evidence of long-term acquired-adaptive natural immunity). Dr. McCullough (see substack below) writes that 'the important point of this case is that a positive ANA can accompany COVID-19 vaccine induced myopericarditis. Give as a gift or purchase for a team or group. CDC to me appears to be writing hit pieces on the administration, Alexander wrote in one email, asking for changes to two already-published reports. The United States had low unemployment and was making strides across the globe. He sought to muzzle federal scientists and public health agencies to prevent them from contradicting the rhetoric coming from the Trump administration. hitType: 'event', Dr. Paul E. Alexander, PhD, has expertise in teaching of epidemiology (clinical epidemiology), evidence-based medicine, and research methodology. But nowhere else will you find a story from within the belly of the beast like Alexander. Thats how they wanted it to be perceived.. eventCategory: event.slot.getSlotElementId(), Epidemiologist and former Covid advisor for the U.S. Department of Health and Human Services Dr. Paul Alexander. Caputo did not respond to a request for comment. Dr. Alexander would not discuss his relationship with Mr. Caputo. To receive new posts and support my work, consider becoming a free or paid subscriber. The person, who asked not to be named because of the sensitivity of the matter, said they were surprised at Alexanders involvement in the White House machinations, but called him the weakest person Ive ever interacted with at McMaster.. Four reinfections were severe enough to lead to acute care hospitalization. To receive new posts and support my work, consider becoming a free or paid subscriber. Unauthorized distribution, transmission or republication strictly prohibited. These findings provide insight into the relative clinical protection that occurs in most children and might help to guide the design of pediatric vaccination regimens., Assessed the ability of T cells to react with Omicron spike in participants who were vaccinated with Ad26.CoV2.S or BNT162b2, and in unvaccinated convalescent COVID-19 patients (n = 70). I'm an academic scientist, and I work with many. Chen et al. eventCategory: event.slot.getSlotElementId(), window.googletag.pubads().addEventListener('slotRenderEnded', function(event) { He has spoken about opening schools and flooding the zone, to ensure a majority of the population is infected. The employee could keep a job and not go into depths of despair and drink and commit suicide, he said. In an email sent on July 4, Paul Elias Alexander, an advisor to Health and Human Services Assistant Secretary for Public Affairs Michael Caputo, said that the administration should open businesses . Paul Alexander has an extensive background to lend a learned voice to review the mistakes made managing the Covid outbreak. https://www.state.nj.us/health/ceohs/documents/eohap/haz_sites/gloucester/train_derail/survey_report.pdf https://www.cdc.gov/niosh/topics/emres/pdfs/TechAssistRptEPRO.pdf Evaluate anti-nucleocapsid antibody (anti-N Ab) seropositivity in mRNA-1273 vaccine efficacy trial participants after SARS-CoV-2 infection during the trials blinded phasenested analysis in a Phase 3 randomized, placebo-controlled vaccine efficacy trialat 99 sites in the UStrial participants were 18 years old with no known history of SARS-CoV-2 infection and at appreciable risk of SARS-CoV-2 infection and/or high risk of severe Covid-19among participants with PCR-confirmed Covid-19 illness, seroconversion to anti-N Abs at a median follow up of 53 days post diagnosis occurred in 21/52 (40%) of the mRNA-1273 vaccine recipients vs. 605/648 (93%) of the placebo recipients (p < 0.001). Substantially less N Ab (nucleocapsid antibodies are highly conserved and stable, unlike the mutable spike protein) emerged in the vaccinated than those who were unvaccinated. However, within the RBD, binding of vaccine-elicited antibodies was more broadly distributed across epitopes compared to infection-elicited antibodies. Full content visible, double tap to read brief content. eventAction: 'render' Dr. Paul Alexander. Dr. Alexander is the former COVID Pandemic evidence-synthesis advisor to World Health Organization (WHO) in Washington, DC (2020), and former Senior Advisor to the White House, specifically for the COVID Pandemic policy in the US government, Health and Human Services (HHS), Washington, DC. 0 0039 Italy; 1 10Days 10k 11 Degrees 111SKIN 120 Lino 1821 Man Made; 2 2005 24COLOURS 2NDDAY; 3 31 phillip lim 3INA; 4 47 Brand 4711 4F 4Organic 4th Reckless; 5 Alexander COVID News-Dr. Paul Elias Alexander's Newsletter is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Both primary MBC populations have similar frequencies in the blood and respond to asecond S1-RBD exposure by rapidly producing plasmablasts with an abundant immunoglobulin (Ig)A+subset and secondary MBCs that are mostly IgG+and cross-react with the B.1.351 variant. Read it and become truly informed about what really happened! The next issue of NP Posted will soon be in your inbox. Alexander COVID News-Dr. Paul Elias Alexander's Newsletter . He is also listed as a principal in a consulting company, e20 Solutions. I've always felt I knew most of what the Deep State was up to, and how powerful they'd become right under our noses. Guns N' Roses, Stevie Nicks, Janet Jackson and Wizkid are on sale now. When I was fourteen years old I submitted my first story to ANALOG magazine, devoted to short science fiction stories. Click this link for the original source of this article. Spike-specific T cell responses were more than twice as high in children and were also detected in many seronegative children, indicating pre-existing cross-reactive responses to seasonal coronaviruses. When new books are released, we'll charge your default payment method for the lowest price available during the pre-order period. Vehemently, Alexander wrote Aug. 27, reported Politico. Notably, these antibody responses were associated with virus-neutralizing activity that was still detectable 4 months after acute infection in 94% of children. I recommend people to read this book from an educated expert in the field. evaluated the protection conferred by mRNA vaccines and previous infection against infection with the omicron variant in two high-risk populations; See Table S4 in supplementary for the important findings, there are zero (0) deaths in the unvaccinated (prior infected) and zero (0) deaths in the vaccinated; the study attempts to champion the vaccine yet the real finding is that there were no deaths on those unvaccinated in a closed high-risk prison population; these prisoners withstood death with their own immunity (natural immunity) and needed no vaccine, Researchers sought to evaluate dynamics of antibody levels following exposure to SARS-CoV-2 during 12 months in Dutch non-vaccinated hairdressers and hospitality staff., Dr. Harvey Risch, MD, PhD (YaleSchool of Public Health), Dr. Howard Tenenbaum, PhD (Faculty of Medicine, University of Toronto), Dr.Ramin Oskoui, MD (Foxhall Cardiology,Washington), Dr. Peter McCullough, MD (Truth for Health Foundation (TFH)), Texas, Dr. Parvez Dara, MD (consultant,Medical Hematologist and Oncologist). document.querySelector("#google_image_div").addEventListener('click',function(){ Alexander COVID News-Dr. Paul Elias Alexander's Newsletter is a reader-supported publication. May we all stand united against such evil entities such as the ones who have done much harm. He is a former COVID Pandemic evidence-synthesis advisor to WHO-PAHO,former Senior Advisor to COVID Pandemic policy in the US government, Health and Human Services (HHS), and a former Assistant Professor at McMaster University in evidence-based medicine. }) This book will go down as a seminal text in the biblical times of Covid, Reviewed in Canada on February 1, 2023, Reviewed in Canada on December 30, 2022, Learn more how customers reviews work on Amazon. There was an error, please provide a valid email address. Additionally, in Omicron-infected hospitalized patients (n = 19), there were comparable T cell responses to ancestral spike, nucleocapsid and membrane proteins to those found in patients hospitalized in previous waves dominated by the ancestral, Beta or Delta variants (n = 49). hitType: 'event', . He was chosen by Caputo as the assistant secretary for public affairs at HHS after Trump expressed that he wanted Caputo to bring expertise to his new position. Outside experts were shocked to hear of the Canadians involvement, not least because of his affiliation with the Hamilton, Ont., university. Additionally, Paul has led institutions of Higher Learning in each of these places. Who is Paul Alexander? He has been a controversial figure in general for his intervention in COVID work by U.S. agencies. -bestselling author Kent Heckenlively, JD, will not only show proof of a presidential takedown, but also of the personal vendetta of the CDC and HHS against Alexander himself. Articles by Paul E. Alexander Authoritarianism, , , Science , Government, Science Visit our Community Guidelines for more information and details on how to adjust your email settings. We found evidence of an increased risk of infection by the Beta (B.1.351), Gamma (P.1), or Delta (B.1.617.2) variants compared to the Alpha (B.1.1.7) variant after vaccination. To receive new posts and support my work, consider becoming a free or paid subscriber. Paul Elias Alexander, Self: The Ingraham Angle. if(document.querySelector("#google_image_div")){ Paul Alexander a part-time professor of health research methods, evidence and impact at McMaster since 2015 moved from Hamilton to Washington, D.C., in late March to advise a leading . As a family member has said all along. eventAction: 'load' I really, really hope that I am wrong, but I do not think so. CDC to me appears to be writing hit pieces on the administration. ga('ads.send', { It must be difficult for [CDC] to be criticized by an Oxford-educated scientist who has been published in peer-reviewed journals 67 times.. He is a former COVID Pandemic evidence-synthesis advisor to WHO-PAHO,former Senior Advisor to COVID Pandemic policy in the US government, Health and Human Services (HHS), and a former Assistant Professor at McMaster University in evidence-based medicine. document.querySelector("#adunit").addEventListener('click',function(){ We would like to show you a description here but the site won't allow us. We cannot understand anything he says, from day to day. Dr. Paul Alexander - 12.19.21 from Greg Muncy on Vimeo. Reinfections were rare and were generally mild, perhaps because of the primed immune system after primary infection., SARS-CoV-2 reinfection can occur but is a rare phenomenon suggestive of protective immunity against reinfection that lasts for at least a few months post primary infection., Analyzed 28,578 sequenced SARS-CoV-2 samples from individuals with known immune status obtained through national community testing in the Netherlands from March to August 2021. Sometimes you make a mess, you are a bumbling idiot and you make a fool of yourself.. Click this link for the original source of this article. Antibody responses against spike protein were high in children and seroconversion boosted responses against seasonal Beta-coronaviruses through cross-recognition of the S2 domain. Using alternative treatments like Dr. Alexander's tale of 2 dichotomies are profoundly informative and frightening at the same time. I did things with good intentions, he said. He is quickly gaining a reputation as one of the most fearless corruption fighters of our time. To assess robustness of mRNA vaccine-induced immunitycompared antibody durability and breadth after SARS-CoV-2 infection and vaccinationWhile vaccination delivered robust initial virus-specific antibodies with some cross-variant coverage, pre-variant SARS-CoV-2 infection-induced antibodies, while modest in magnitude, showed highly stable long-term antibody dynamicsDifferential antibody durability trajectories favored COVID-19-recovered subjects with dual memory B cell features of greater early antibody somatic mutation and cross-coronavirus reactivityilluminating an infection-mediated antibody breadth advantage and an anti-SARS-CoV-2 antibody durability-enhancing function conferred by recalled immunity., Compare antibody and cellular immunity in children (aged 3-11 years) and adults. Dr. Paul Alexander I am a COVID-19 Consultant Researcher in EBM, Research Methodology, and Clinical Epidemiology and I informally provide support to some members of the US Congress and Senate. The assistant professorship is an unpaid position given to scholars working primarily outside the university. The missives were sent by Paul Alexander, a part-time professor at Canadas McMaster University, an institution lauded worldwide for its dedication to the highest standards in medical research. A typical entry lists information in the following sequence: Name, age, country of citizenship at birth, subsequent country of citizenship (if applicable), reason for notability, cause of death (if known), and reference. media-tech companies with hubs around the world. Paul Elias Alexander, former Senior Advisor to COVID Pandemic policy in the US government for President Trump and formerCOVID Pandemic evidence-synthesis advisor to WHO-PAHO, was on the frontlines to watch how Trump's world, and his reelection hopes, slowly collapsed leading up to November 2020due to the CDC, NIH, and WHO conspiring to overthrow him with the worst response possible to the COVID crisis.Supported by emails and documents, careerepidemiologist Alexander andNew York Times-bestselling author Kent Heckenlively, JD, will not only show proof of a presidential takedown, but also of the personal vendetta of the CDC and HHS against Alexander himself. This advertisement has not loaded yet, but your article continues below. Un Jardin a Cythere is inspired by the Greek island of Kythira. U.S. President Donald Trump holds a briefing on COVID-19 developments at the White House, August 23, 2020. Then came COVID-19.Dr. Alexander COVID News-Dr. Paul Elias Alexander's Newsletter is a reader-supported publication. The Wuhan Cover-Up: How US Health Officials Conspired with the Chinese Military to Hide the Origins of COVID-19 (Childrens Health Defense), The Parallel Election: A Blueprint for Deception : Evidence of Massive Election Fraud in Delaware County, Pennsylvania, The Nation Will Follow: First-hand experiences fighting the Deep State and the Action Plan for the American Citizen. His letter to Robert Redfield read, we essentially took off the battlefield the most potent weapon we hadyounger healthy people, children, teens, young people who we needed to fastly [sic] infect themselves, spread it around, develop immunity, and help stop the spread.Even though HHS Secretary Alex Azar testified that herd immunity was not a strategy of the US government, one of Trump's former appointees implied that It was understood that he spoke for Michael Caputo, who spoke for the White House. Setting: Nationally centralized database of Maccabi Healthcare Services, an Israeli national health fund that covers 2.5 million people. There has been a noticeable increase in cases of autoimmune hepatitis (AIH) after COVID vaccination. As a Board Certified Cardiologist, Internist and Owner of 3 High level Urgent Cares I have been engaged with CV 19 since the beginning. The President has often played down the seriousness of the pandemic, which has killed more than 200,000 Americans. N ' Roses, Stevie Nicks, Janet Jackson and Wizkid are on sale now your payment! More broadly distributed across epitopes compared to infection-elicited antibodies an educated expert in the field COVID... From Greg Muncy on Vimeo the pre-order period a controversial figure in general for his intervention in COVID by! From day to day a noticeable increase in cases of autoimmune hepatitis ( AIH ) after COVID.... Months after acute infection in 94 % of children continues below describes Alexander as expert... 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