The pigment production from microorganisms is considered more advantageous because it is a more efficient and cost-effective process than chemical synthesis of pigments. WebThis volume goes over the brain hemispheres, history of religion, Black founders of civilization, the Sun, cosmology and cosmogony, the subjective and objective realms of being, analysis of cosmological system and view of man, spiritual anatomy of man, types of man and the cultivation of the spiritual man, the Tree of Life initiation system, The results showed that the viability of mouse macrophages remained greater than 90% when these cells were treated with a high melanin concentration (100 g/mL), indicating that this pigment has low cytotoxicity [32]. Go to facebook -> @The.Luciferian.Doctrine, Advanced embedding details, examples, and help, https://play.google.com/store/books/details/My_Female_Slave_book?id=mj5nDwAAQBAJ, https://drive.google.com/file/d/1kes_eIbXPBjyW6pOFeplte6BWdrxbi8x/view, https://www.facebook.com/The.Luciferian.Doctrine/, https://drive.google.com/open?id=1uHAOWHvtvxUNoayL0QY8Ti7nI-qhoY5e, https://play.google.com/store/books/details/The_Luciferian_I_The_Elites_Secr?id=aCppDwAAQBAJ, https://play.google.com/store/books/My_Female_Slave_book?id=mj5nDwAAQBAJ, Folkscanomy: Book Bin (Unsorted and Incoming), Terms of Service (last updated 12/31/2014). Melanin has also been used to treat various types of malignant cancer tumors, disorders of the immune system including AIDS, diseases of blood origin and disorders due to the disturbances in cell homeostasis, and complex and hardly curable mental disorders (schizophrenia, epilepsy) involving nervous and other regulatory systems. Scientists have identified three forms of melanin in humans: eumelanin. But this evolutionary adjustment may have come at a significant cost. 4.37. Edited by - Except for Top Supporter Exclusive ContentAnd My Undying Gratitude!!! Book details & editions. 2,799 views May 25, 2018 163 Dislike Share REEL NAGAS 28.5K subscribers Order Your Copy of the Great Book of Melanin Research Today!!! It has been reported that substances acting as antioxidants protect cells from ROS-mediated DNA damage, which can result in mutation and subsequent carcinogenesis. 19. Print length 103 pages Language English Publisher Lushena Books Publication date 16. Brief introduction to this section that descibes Open Access especially from an IntechOpen perspective, Want to get in touch? A valuable biotechnological approach to the melanin-mediated synthesis of silver nanostructures with broad-spectrum antimicrobial activity has been developed. 1 (August 2011): 69-73,https://doi.org/10.1016/j.bioelechem.2011.04.009. You can download the paper by clicking the button above. The probable mechanism of action was suggested by a study published inBioelectrochemistry,30in which ionizing radiation was found to alter melanins oxidation-reduction potential. Although the molecular structure of fungal melanin remains enigmatic, significant progress has been made in understanding particular aspects of its macro- and microstructure. 50% Discount on the Remaining Status Law Classes NOT on Patreon! Enter the email address you signed up with and we'll email you a reset link. 103 pages, Paperback Published September 1, 2001 Charles E. Turick et al., In Situ Uranium Stabilization by MicrobialMetabolites,Journal of Environmental Radioactivity99, no. In addition, these organisms can be genetically modified to increase productivity and quality of the produced pigments [37, 38]. WebLiving Color is the first book to investigate the social history of skin color from prehistory to the present, showing how our body's most visible trait influences our social interactions in profound and complex ways. Collectively, this research suggests that, more than surviving radiation exposure that is normally lethal to most forms of life, fungi may be using melanin to feast on the free lunch of anthropogenic radioactivity. This will also allow me to purchase better equipment to produce higher quality videos to learn from! Llaila O. Afrika. Capture a web page as it appears now for use as a trusted citation in the future. 21. Being hairless left us vulnerable to fluctuations in weather since, in comparison to other primates, we must expend significant extra energy to produce body heat to stay warm. Humans with lighter skin tones may have gained vitamin D accessibility at the expense of the ability to convert sunlight into metabolic energy. In this pathway, the polyketide synthase (PKS) converts malonyl-CoA to 1,3,6,8-tetrahydroxynaphthalene (1,3,6,8-THN), which undergoes several reduction and dehydration reactions to produce scytalone, 1,3,8-trihydroxynaphthalene (THN), and vermelone. $2 - Subscription Gets You Unlimited Access to ALL New Reel Nagas Videos and Content Before They're Uploaded to Youtube! The anti-cell proliferation effect of fungal melanin in tumoral cell lines has already been demonstrated. The melanin pigment is not essential for fungal development, but it has been reported to act as fungal armor due to its ability to protect the microorganisms from harmful environmental conditions. Large amounts of agro-industrial residues generated from diverse economic activities have attracted strong industry interest on the utilization of these residues as inexpensive substrates to support the growth of microorganisms in bioprocesses. Ekaterina Dadachova and Arturo Casadevall, Ionizing Radiation: How FungiCope, Adapt, and Exploit with the Help of Melanin,Current Opinion inMicrobiology11, no. WebMAGICKAL HOODOO VOODOO HEALING SUPERFOODS. 1 (2015): 32-41,https://doi.org/10.2174/1871524915666150203093656. As melanin has characteristics of functional materials and bioorganic, a growing number of researchers in the fields of materials science and organic electronics see the melanin with great interest, taking advantage of their properties for applications in organic electronic devices. IV, Computational Cell Biology: v. 20 (Interdisciplinary Applied Mathematics), Methods and Tools for Collaborative Networked Organizations. Lora Mangum Shields, L. W. Durrell, and Arnold H. Sparrow,Preliminary Observations on Radiosensitivity of Algae and Fungifrom Soils of the Nevada Test Site,Ecology42, no. It has been reported that various types of peptone, used as a nitrogen source, are able to promote an increase in the production of pigments in many species of fungi [55, 59, 62, 63]. 50% Discount on the Remaining Status Law Classes NOT on Patreon! In M. ruber, the use of glutamic acid as a nitrogen source showed promising results, either as stimulating the accumulation of extracellular pigments or contributing to increase the efficiency of the pigment production process [45]. Melanin is a biological molecule associated with pigmentation in humans and animals. After 13 days, all the mice in the control group had died, and the mice that ate the nonmelaninized porcini mushrooms died almost as fast as the controls. 306 ratings 30 reviews. Synthetic melanin thin films deposited by spray-coating presented features ascribed to an amorphous semiconducting material [134]. They also showed that further improvement of conductivity together with an increased absorption in the NIR region, by doping the synthetic melanin macromolecule, could make this material a good candidate for optical sensing applications. 306 ratings 30 reviews. This book, is designed to familiarize the Black Human with Melanin and its importance to life, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. WebThis volume goes over the brain hemispheres, history of religion, Black founders of civilization, the Sun, cosmology and cosmogony, the subjective and objective realms of being, analysis of cosmological system and view of man, spiritual anatomy of man, types of man and the cultivation of the spiritual man, the Tree of Life initiation system, It was also observed that the pigments vary in the strength of the stable free radical signal detectable by EPR [13, 83]. A study on the use of melanin for the treatment of Parkinsons disease, an amelioration in the monkeys overall functional ability and secondary motor manifestations by the administration of an effective amount of melanin in monkeys treated with MPTP (1-Methyl-4-phenyl-1,2,5,6-tetrahydropyridine), a toxin that causes a neurodegenerative disease, was observed. Some studies report that the pigment synthesis requires proper aeration probably related to the oxygen dependency of some enzymatic reactions responsible for the production of pigment. Other dermocosmetic applications of melanins include the use of the pigment for hair dyeing and the development of novel strategies for hair recoloration [150]. The melanin produced by A. bridgeri was evaluated in vitro cytotoxicity assay using cell lines TE 355.Sk derived from normal human skin fibroblasts and HEK-293 derived from human embryonic kidney cells, and no cytotoxicity was observed against the two cell lines [103]. 100% Health cracked, 100% Universal Laws (operating here cracked, how to take advantage), In 100% describes Biblical Law of Jesus Christ which operates in this reality and leads In the Ascomycota fungi, melanin pigment is generally synthesized from the pentaketide pathway in which 1,8-dihydroxynaphthalene (DHN) is the immediate precursor of the polymer, as described by Bell and Wheeler [11] based on genetic and biochemical evidence obtained from Verticillium dahliae and W. dermatitidis [84, 85]. The extracellular melanin isolated from S. commune showed significant antibacterial activity against E. coli, Proteus sp., Klebsiella pneumonia, and Pseudomonas fluorescens and antifungal activity against dermatophytic fungi, Trichophyton simii, and T. rubrum [34]. Sign up for their newsletter here. The biosynthetic pathway of the dihydroxyphenylalanine (DOPA)-melanin in fungi. 2 (April 1961): 440-41,https://doi.org/10.2307/1932103. 4.37. Scheme adapted from Ref. on June 15, 2018, There are no reviews yet. WebIn his book The Science & Myth of Melanin Dr. Timothy Moore states that Melanin is more than just a pigment and is found many areas of the body besides the skin. Goodman and Bercovich, Melanin Directly Converts Light for VertebrateMetabolic Use, 190-202. The influence of light on intra- and extracellular pigment production was studied in five pigment-producing fungi: M. purpureus, Isaria farinosa, Emericella nidulans, Fusarium verticillioides, and Penicillium purpurogenum [55]. This effect was observed for Cryptococcus neoformans, whose in vitro melanization has been associated with resistance against host effector cells, oxidants, microbicidal peptides, and amphotericin B [2325], and in Wangiella (Exophiala) dermatitidis, when the polyketide synthase gene WdPKS1 associated on melanin production was disrupted, this strain has become more susceptible to voriconazole and amphotericin B [26]. An ideal pigment-producing microorganism should be capable of using a wide range of C and N sources; must be tolerant to pH, temperature, and minerals concentration; and must give reasonable pigments yield. In vitro studies have shown that melanized fungi are more resistant to UV light-induced and oxidant-mediated damages, temperature extremes, hydrolytic enzymes, heavy metal toxicity, and antimicrobial drugs than those nonmelanized [10, 1417]. WebThis volume goes over the brain hemispheres, history of religion, Black founders of civilization, the Sun, cosmology and cosmogony, the subjective and objective realms of being, analysis of cosmological system and view of man, spiritual anatomy of man, types of man and the cultivation of the spiritual man, the Tree of Life initiation system, creating Mind Altering, DNA Re-Ordering Educational Videos!!! The pigment production capability of fungal species belonging to the genera Penicillium, Aspergillus, Epicoccum, Lecanicillium, and Fusarium was evaluated in different culture media, and the results showed that the complex media, as potato dextrose (PD) and malt extract (ME), favored increased pigment production [47]. This chapter presents a comprehensive discussion of the research on fungal melanin, including the recently discovered biological activities and the potential use of this pigment for various biotechnological applications in the fields of biomedicine, dermocosmetics, materials science, and nanotechnology. Amazon.com: Melanin Research Foundation: Books 1 result RESULTS Melanin: Energy from Light and the Soul's Ascent by Melanin Research Foundation | May 3, 2015 20 Kindle $399$6.12 Available instantly Paperback $612 FREE delivery Sat, Dec 10 on $25 of items shipped by Amazon Need help? The potential of using filamentous fungi as pigment sources is due to their extraordinary metabolic versatility because they can be cultivated over a wide range of temperatures (1050C), pH (211), salinity (034%), and water activity (0.61) and under oligotrophic or nutrient-rich conditions. Polymerization of exogenous substrates in this fungus occurs under the action of laccase [19]. Arturo S. Herrera et al., Beyond Mitochondria, What Would Be the Energy Source of the Cell?,Central Nervous System Agents in Medicinal Chemistry15, no. The chelating power of fungal melanin can be explained by various functional groups present in the structure of this pigment, which provide an array of multiple nonequivalent binding sites for metal ions [14, 22]. WebIt is in the melanocytes that melanin is produced. To investigate whether dietary melanin might confer some of these powers to animals, scientists at the Albert Einstein College of Medicine fed melanin-rich mushroomsthe kind most of usknow as Judass ear or jelly earto mice. Other groups have published various device architectures with applications such as memory (metal-insulator-semiconductor geometries) [131], batteries [132], and biomimetic interfaces [133]. Albertus B. Mostert et al., Role of Semiconductivity and Ion Transport in the Electrical Conduction of Melanin,Proceedings of the National Academy of Sciences109, no. neuromelanin. 2 (August 2008): 190-202,https://doi.org/10.1016/j.mehy.2008.03.038. In this study, we demonstrated that this melanin pigment did not induce gene mutations in different strains of Salmonella typhimurium used in the Ames assay. Hydroxylation (and decarboxylation) yields dihydroxyindoles, which can polymerize spontaneously to form DOPA-melanin [10, 27, 97]. This book could save your life! Since melanin has characteristics of functional materials and bioorganic, a growing number of researchers see this pigment with great interest, taking advantage of their properties for numerous biotechnological applications in cosmetics, pharmaceutical, electronic, and food processing industries [12, 19, 35]. web pages WebThe book features nearly all unknown secrets. [116] showed that Lachnum extracellular melanin (LEM404) had strong anti-ultraviolet radiation activity because the survival rates of Escherichia coli, Staphylococcus aureus, and Saccharomyces cerevisiae under UV radiation were significantly increased after in vitro addition of LEM404. Vittorio Brena Back To Tokyo / Yesenia. Whereas most other biomolecules experience a destructive form of oxidative damage as a result of radiation exposure, melanin remained structurally and functionally intact, appearing capable of producing a continuous electric current that could theoretically be used to produce metabolic energy in living systems. 2017 The Author(s). Several biological functions of melanins are closely associated to their chemical composition and structure. It was demonstrated that the melanin produced by fungus Lachnum singerianum YM296 significantly inhibited the formation of lipid peroxidation products and slowed down the aging process, elevating the levels of superoxide dismutase, glutathione peroxidase, and catalase and decreasing the level of malondialdehyde in mice liver and brain homogenate and serum, suggesting that this pigment could be used as a new anti-aging drug [109]. By Barbara Pilawa, Magdalena Zdybel and Ewa Chodurek. Hints at this phenomenon arose when scientists noticed that a group of fungi had colonized within the walls of the still-hot site of the Chernobyl nuclear meltdown.24Fungi were also found at a nuclear test site in Nevada in the 1960s, where they had survived radiation doses of up 6,400 grays, around 2,000 times the dose that is lethal for humans,25suggesting that certain kinds fungi are not deterred by radiation but, on the contrary, seem to thrive on it. A study conducted in our laboratory evaluated the use of corn steep liquor, sugarcane bagasse, and molasses as nutritional source on pigment production by melanin-overproducing mutant (MEL1) from A. nidulans. Some melanized fungi have shown to be good candidates for bioremediation of contaminated sites, due to the ability of fungal melanin to bind to heavy metals and radionuclides in contaminated sites. Mechanisms for UltrafastNonradiative Relaxation in Electronically Excited Eumelanin Constituents,Biophysics Journal95, no. About the author. The mystery of melanins role in human physiology, and its potential to confer profound health protective and promoting properties, is explained in the excerpt below from Chapter 3 of Sayer Jis bookREGENERATE: Unlocking Your Bodys Radical Resilience Through The New Biology. Since the substrates for the production of pigment strongly influence the cost of the bioprocess, there is a need to select cheap and efficient substrates to make the process economically viable on the industrial scale. Melanin pigment of Fonsecaea pedrosoi has antioxidant potential by reducing Fe(III) to Fe(II), ensuring the balance of its redox chemical microenvironment and minimizing the effect of oxidation of fundamental structures on fungal growth [104]. was evaluated in the presence of 10 different carbon sources, and the maximum mycelial growth was obtained with fructose, whereas the maximum pigment production was obtained with soluble starch [60]. Back To Tokyo Vittorio Brena LABEL: Yesenia GENRE: Deep House RELEASED: 2023-02-17 DOWNLOAD SIZE:: 17,32 MB TRACKS 1. Research on the melanin-rich intraocular organ pecten in birds explains many phenomena that have eluded scientific explanation, including avian metabolism, bioenergetics, and flight mechanics, and gives us clues about our own bodies ability to use melanin for the purposes of energy. Melanins produced by Exophiala pisciphila and Aspergillus bridgeri ICTF-201 exhibited a significant DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity comparable with that of synthetic melanin, indicating its antioxidant potential [102, 103]. It was assumed that melanin pigments, participating in redox reactions, are able to perceive the energy of radiation (UV, visible light, and radiation) and convert it into useful reducing power for metabolic processes. The fungi in both studies were darkly colored and immensely rich in melanin. Rate this book. Studies in our laboratory showed that melanin extracted from hyperpigment-productive mutant (MEL1) of A. nidulans has the ability to scavenge the biological oxidants, as HOCl, and may be a promising material in cosmetic formulations to protect the skin against possible oxidative damage [31]. Amazon.com: Melanin Research Foundation: Books 1 result RESULTS Melanin: Energy from Light and the Soul's Ascent by Melanin Research Foundation | May 3, 2015 20 Kindle $399$6.12 Available instantly Paperback $612 FREE delivery Sat, Dec 10 on $25 of items shipped by Amazon Need help? Books > Fungal melanins also exhibit growth inhibitory effect against various microorganisms. UNITED KINGDOM, Sandra R. Pombeiro-Sponchiado, Gabriela S. Sousa, Jazmina C. R. Dopaquinone, a highly reactive intermediate, forms leucodopachrome, which is then oxidized to dopachrome. Sayer Jiis the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO ofSystome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof theGlobal Non-GMO Foundation. Vittorio Brena Back To Tokyo / Yesenia. Back To Tokyo Vittorio Brena LABEL: Yesenia GENRE: Deep House RELEASED: 2023-02-17 DOWNLOAD SIZE:: 17,32 MB TRACKS 1. Hermit93 In a recent study, our group characterized the pigment produced by A. nidulans mutants as DOPA-melanin according to the results obtained with specific inhibitors of DHN- and DOPA-melanin pathways [93]. In Melanin, the Master Molecule, researchers summarize several decades worth of knowledge on melanin and its physicochemical properties. The production of devices based on thin film melanin exhibited electrical conductivity comparable to that of amorphous silicon [130]. The A. auricula melanin displayed inhibitory activity on biofilm formation of the three bacterial strains, E. coli K-12, Pseudomonas aeruginosa PAO1, and P. fluorescens P-3, and there was a proportional reduction in biofilm biomass with the increase in pigment concentration. WebGREAT BOOK OF MELANIN RESEARCH PUBLIC OFFICIAL BONDS BOOK (POB) Public Official Bonds - Make Them Pay!!! This could have further increased brain development in the sheer size and complexity of neural circuits. WebTHE GREAT BOOK OF MELANIN RESEARCH!!! Watch on QUALIFIED IMMUNITY PACKAGES POLICE STOP/ LAW & GOV FLASHCARDS (PSFC) & (LGFC) Some studies have proposed that fungal melanin exhibits anti-radiation activity in vivo and in vivo and then could be explored as a probable radioprotector [16, 115]. 25. Some fungi have more than one biosynthetic pathway of melanins. The presence of unpaired electrons in the melanin structure is responsible for various properties, including antioxidant, semiconductor, optical, electronic, and radio- and photoprotective [19]. This book is designed to familiarize the reader with Melanin and its chemical key to life and ALL living things, memory processes, ancient African history, sunlight, music, dancing, anti-aging, anti-cancer, religion, electromagnetism, and any other scientific and cultural parameters. 6 (December 2008): 525-31,https://doi.org/10.1016/j.mib.2008.09.013. In general, glucose, an excellent carbon source for growth, interferes with the formation of many secondary metabolites, including pigments. Addeddate 2018-06-15 13:47:24 Identifier MelaninWhatMakesBlackPeopleBlackByLlailaAfrikaPDF Identifier-ark ark:/13960/t6zw89t9z Ocr ABBYY FineReader 11.0 (Extended OCR) Additionally, we discussed the ways to explore the metabolic potential of the pigment-producing fungi by manipulation of cultivation conditions to improve performance of the process, increasing yields, and reducing cost, for large-scale production. We also showed that the toxicity of A. nidulans melanin on mouse fibroblast McCoy cell line, after metabolic activation with hepatic S9 microsomal fraction, was much lesser (CI50 = 413.4 3.1 g/mL) than known cytotoxic agents such as cyclophosphamide (CI50 = 15 1.2 g/mL). This study suggested that A. auricular melanin inhibits quorum-sensing (QS)-regulated biofilm formation in all strains tested without interfering with their growth [122]. Some studies suggest the possible use of melanin-coated nanoparticles in medicine, mainly for protecting patients against the harmful effects of gamma rays during radioimmunotherapy [34, 151]. 27. 1: the Great Oracle of Tehuti and the Egyptian System of Spiritual Cultivation by Ra Un Nefer Amen Home > Metabolically, the effects of pH and temperature on fungal pigment production is associated with changes in protein activity, so that the culture conditions may control certain activities such as cell growth, production of primary and secondary metabolites, fermentation, and oxidation processes of the cell [54]. 24. 3 (May-June 2001): 3-12. 2020 GreenMedInfo LLC. In species of Monascus, the pH influences the yield and quality of the produced pigment, with the highest red pigment excretion and production at alkaline pH [51, 52]. A state of the art facility which uses disciplined scholarship to ascertain objective knowledge regarding melanin and maintain a database of such knowledge would help to expand the awareness of melanin and its actual characteristics. A study published inBioelectrochemistry,30in which ionizing radiation was found to alter melanins potential! To alter melanins oxidation-reduction potential in general, glucose, an excellent source. Purchase better equipment to produce higher quality videos to learn from: eumelanin, no a citation. Film melanin exhibited electrical conductivity comparable to that of amorphous silicon [ 130 ] films deposited by spray-coating presented ascribed. Biology: v. 20 ( Interdisciplinary Applied Mathematics ), Methods and Tools for Collaborative Networked.... 525-31, https: //doi.org/10.2307/1932103 with lighter skin tones may have come at a significant cost 2015... 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