If chorionic villi are seen, further workup is unnecessary, and exposure to methotrexate can be avoided(Figure 1).5,1517,21 If chorionic villi are not seen after uterine aspiration, it is imperative to initiate treatment for ectopic pregnancy or repeat -hCG measurement in 24 hours to ensure at least a 50% decrease. It can be helpful to jot down your questions for the doctor before your visit. If an ultrasound doesnt show an embryo in your uterus, it could be that its too early in pregnancy to see the embryo, or it could be an ectopic pregnancy. If you wish to try to get pregnant again, it's very important to see your doctor regularly. These may include pain, fatigue, bleeding, and infection. The discriminatory level varies with the type of ultrasound machine used, the sonographer, and the number of gestations. If theres a mass in the area of the fallopian tubes or ovary, this may represent an ectopic pregnancy. This type of ectopic pregnancy is called a tubal pregnancy. If ectopic pregnancy has been diagnosed, the patient is deemed clinically stable, and the affected fallopian tube has not ruptured, treatment options include medical management with intramuscular methotrexate or surgical management with salpingostomy (removal of the ectopic pregnancy while leaving the fallopian tube in place) or salpingectomy (removal of part or all of the affected fallopian tube). After the injection, your doctor will order another HCG test to determine how well treatment is working, and if you need more medication. The search included meta-analyses, randomized controlled trials, clinical trials, guidelines, and reviews. Urine tests. An intra-uterine pregnancy can usually be seen by 5-6 weeks gestation or when the HCG level is more than 1000 IU/l. Treatment options for early pregnancy loss include expectant management, medical management with mifepristone and misoprostol, or uterine aspiration. "hCG helps the body produce hormones to support pregnancy," explains John Zhang, M.D., founder. Watchful waiting is recommended as first-line treatment for patients with incomplete abortion; more than 90% of these patients will complete the process spontaneously within four weeks.24 Watchful waiting is less effective in patients with an anembryonic gestation or embryonic demise, with completion rates at one month of 66% and 76%, respectively.24 Patients who choose expectant management over uterine aspiration experience more days of bleeding, longer time to completion, and higher rates of unplanned surgical intervention.20,21 Serious complications are rare, and patients who opt for expectant management should be informed that it is safe to wait as long as they wish as long as there are no signs of infection or hemorrhage. Ectopic pregnancy. A Cochrane review found that medical management with misoprostol (Cytotec) in women with incomplete abortion does not improve rates of completed abortion or decrease the need for unplanned surgical procedures compared with expectant management.22 In contrast, medical management is more effective than expectant management for the treatment of anembryonic gestation or embryonic demise.25 The most effective regimen for medical management is 200 mg of oral mifepristone (Mifeprex) followed 24 hours later by 800 mcg of vaginally administered misoprostol.26 Success rates at two days with this regimen are 84% vs. 67% in those treated with misoprostol alone. Other potential symptoms include presyncope, syncope, vomiting, diarrhea, shoulder pain, lower urinary tract symptoms, rectal pressure, or pain with defecation.11, The physical examination can reveal signs of hemodynamic instability (e.g., hypotension, tachycardia) in women with ruptured ectopic pregnancy and hemoperitoneum.12 Patients with unruptured ectopic pregnancy often have cervical motion or adnexal tenderness.13 Sometimes the ectopic pregnancy itself can be palpated as a painful mass lateral to the uterus. There is insufficient evidence to support the use of progestin for the prevention of early pregnancy loss.3,18 Bed rest does not improve outcomes and may cause psychological harm in patients with subsequent early pregnancy loss.19 Patients should be reassured that nothing they did caused the bleeding. A person viewing it online may make one printout of the material and may use that printout only for his or her personal, non-commercial reference. Taking methotrexate can have some side effects. include protected health information. information is beneficial, we may combine your email and website usage information with Additionally, a PubMed search was completed in Clinical Queries using the following key terms: first trimester bleeding, threatened abortion, miscarriage, ectopic pregnancy, and discriminatory zone. All rights reserved. You may feel abdominal discomfort or pain. Have you ever had reproductive surgery, including getting your tubes tied (or a reversal)? However, if a person's hCG level is rising slowly or decreasing, this suggests that the pregnancy may be ectopic. A fertilized egg can't develop normally outside the uterus. Patients undergoing expectant management must receive extensive counseling on the risk of tubal rupture and the importance of close surveillance. It typically takes from one to nine weeks for hCG levels to return to zero following a miscarriage (or delivery). ERIN HENDRIKS, MD, HONOR MACNAUGHTON, MD, AND MARICELA CASTILLO MACKENZIE, MD, Related letter: Progestin Therapy Not Likely to Be Harmful in Women with First Trimester Bleeding. An hCG level between 6 and 24 mIU/mL is considered a grey area, and you'll likely need to be retested to see if your levels rise to confirm a pregnancy. An ectopic pregnancy is when a fertilized ovum implants outside of the uterus. In the case of an ectopic pregnancy, the hCG level may just plateau or increase at a very slow rate. Tonick S, Conageski C. Ectopic Pregnancy. In 95% of ectopic pregnancy cases, a good transvaginal ultrasound examination can actually image the ectopic pregnancy in the Fallopian tube. Therefore, in a desired pregnancy, it is recommended that a discriminatory level as high as 3,500 mIU per mL (3,500 IU per L) be used to avoid misdiagnosis and interruption of a viable pregnancy, although most pregnancies will be visualized by the time the -hCG level reaches 1,500 mIU per mL.18,19. Advertising revenue supports our not-for-profit mission. In fact, a 2017 study into hCG found that "the slowest or minimal rise for a normal viable intrauterine pregnancy was 24% at one day and 53% at two days. Others may present in shock because their fallopian tube ruptured, causing internal bleeding. The discriminatory level (1,500 to 3,000 mIU per mL) is the -hCG level above which an intrauterine pregnancy should be visible on transvaginal ultrasonography. How long should I wait before trying to become pregnant again? Symptoms of ectopic pregnancy develop between weeks 4 and 12 of pregnancy (or about two to 10 weeks after fertilization). Data Sources: An evidence summary generated from Essential Evidence Plus was reviewed and relevant studies referenced. Prescription pain medication and nonsteroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen. It is appropriate for family physicians to treat hemodynamically stable patients in conjunction with their primary obstetrician. Other factors that may increase a womans risk of ectopic pregnancy include: Use of assisted reproductive technology, such as in vitro fertilization (IVF). Four weeks postoperatively, serum -HCG levels had a . You may seek medical attention due to pain or vaginal bleeding. information and will only use or disclose that information as set forth in our notice of hCG levels at 6 weeks: 1,080-56,500 mIU/ml hCG levels at 7-8 weeks: 7,650-229,000 mIU/ml hCG levels at 9-12 weeks: 25,700-288,000 mIU/ml hCG levels at 13-16 weeks: 13,300-254,000 mIU/ml hCG levels at 17-24 weeks: 4,060-165,400 mIU/ml hCG levels at 25-40 weeks: 3,640-117,000 mIU/ml hCG levels if not pregnant: 0-5 mIU/ml McGraw-Hill Education; 2018. https://accessmedicine.mhmedical.com. The nature, location, and severity of pain in ectopic pregnancy vary. Levels should then double every 48 hours from weeks four to six, but that isn't the case for everyone. Have you had a sexually transmitted infection? The risk factors for ectopic pregnancy include the following: Certain sexually transmitted infections (STIs). If we combine this information with your protected An ectopic pregnancy most often happens in your fallopian tube (a structure that connects your ovaries and uterus). Abdominal ultrasound, in which an ultrasound wand is moved over your belly, may be used to confirm your pregnancy or evaluate for internal bleeding. it is recommended that a discriminatory level as high as 3,500 mIU per mL (3,500 IU per L) be used to avoid misdiagnosis and interruption of a viable pregnancy, although most pregnancies will be visualized by the time the -hCG level reaches 1,500 mIU per mL. The clinical diagnosis of ectopic pregnancy is based on a combination of serum quantitative human chorionic gonadotropin levels and transvaginal ultrasound findings. Seek care right away if you have symptoms of a rupture, including sudden abdominal pain, shoulder pain, or weakness. An hCG level that is lower than expected is one reason to suspect an ectopic pregnancy. Cigarette smoking alters sialylation in the Fallopian tube of women, with implications for the pathogenesis of ectopic pregnancy. It is not a substitute for the advice of a physician. You will not be able to use methotrexate if you are breastfeeding or have certain health problems. The rate of -hCG increase is less rapid as the level increases. A Cochrane review found no difference in success rates between laparoscopic salpingostomy and medical treatment with systemic methotrexate, as well as no differences in tubal patency or subsequent fertility rates.40. privacy practices. 2020;101(10):599-606. https://www.aafp.org/pubs/afp/issues/2020/0515/p599.html, Long Y, Zhu H, Hu Y, et al. As an ectopic pregnancy grows, more serious symptoms may develop, especially if a fallopian tube ruptures. . This blood test may be repeated every few days until ultrasound testing can confirm or rule out an ectopic pregnancy usually about five to six weeks after conception. Copyright 2023 American Academy of Family Physicians. Hemorrhage was the leading cause of death. It can take time for the level of hCG in your body to drop after treatment for an ectopic pregnancy. Levels of this hormone increase during pregnancy. This content is owned by the AAFP. Pregnancy blood tests can detect hCG hormone levels as low as 5 to 10 mIU/mL. Author disclosure: No relevant financial affiliations. Pregnancy of unknown location. Human chorionic gonadotropin, or hCG, is a hormone produced by the placenta during pregnancy. Symptoms may include the following: Sudden, severe pain in the abdomen or pelvis. Read common questions on the coronavirus and ACOGs evidence-based answers. Have you been pregnant before? Uterine aspiration should be considered to evaluate for intrauterine chorionic villi in patients with a pregnancy of unknown location. Make a donation. 25th ed. The first measurement helps the clinician decide between the one- and two-dose protocols. Endometriosis: A condition in which tissue that lines the uterus is found outside of the uterus, usually on the ovaries, fallopian tubes, and other pelvic structures. Other times, a person will have pain in the pelvis thats much worse on one side. Miscarriage. Are you being treated for any other medical conditions? Another possibility is that you could be experiencing a miscarriage. information submitted for this request. Uterus: A muscular organ located in the female pelvis that contains and nourishes the developing fetus during pregnancy. This can also help determine whether a pregnancy is healthy or ectopic, but it should be interpreted together with ultrasound findings. For trusted, in-depth advice from ob-gyns, turn to Your Pregnancy and Childbirth: Month to Month. Pain and heavy bleeding are associated with an increased risk of early pregnancy loss. Other instruments can be used with it to perform surgery. It uses sound waves to create images of your uterus, ovaries and fallopian tubes, and sends the pictures to a nearby monitor. | https://www.uptodate.com/contents/search. These medications can affect the way methotrexate works in the body. . Most women have some abdominal pain. Ectopic pregnancies and normal pregnancies require very different medical management. 2019;14(8):e0219351. Patient preference should guide treatment decisions. Ectopic pregnancy occurs when a fertilized ovum implants outside of the uterine cavity. Ectopic pregnancies occur in approximately 1.3 to 2.4% of pregnancies. General Anesthesia: The use of drugs that produce a sleep-like state to prevent pain during surgery. At-home urine tests require higher levels of hCG to detect a pregnancy, typically at least 20 mIU/mL. Treatment of threatened abortion is expectant management. Completed early pregnancy loss should be confirmed by one of the following: visualization of products of conception on examination or after uterine aspiration; ultrasonography showing the absence of an intrauterine pregnancy after previous ultrasonography documenting an intrauterine pregnancy; or a decrease in -hCG levels by at least 50% at two days or 87% at seven days.31 Once completion is confirmed, the -hCG level does not need to be followed to zero, except in women with pregnancy of unknown location, or if gestational trophoblastic disease is being considered because of abnormal uterine bleeding or symptoms of malignancy.32, Patients who wish to use contraception after early pregnancy loss can start immediately. Also searched were the Cochrane database, the Agency for Health-care Research and Quality, DynaMed, and the National Guideline Clearinghouse. 2016;83(12):1083-1091. doi:10.1002/mrd.22747. An intra-uterine pregnancy can usually be seen by 5-6 weeks gestation or when the HCG level is more than 1000 IU/l. Are you in pain? You may continue to feel pregnant for a while. A choice of either methotrexate or surgical management is offered to women with an ectopic pregnancy who have a serum hCG level of at least 1500 IU/L and less than 5000 IU/L, . Foods that produce gas, which can cause discomfort and mask the pain of a possible rupture of a fallopian tube. It is not intended as a statement of the standard of care. Salpingostomy and salpingectomy are two laparoscopic surgeries used to treat some ectopic pregnancies. Cochrane Database of Systematic Reviews. It may take a few cycles for your periods to return to normal. Pregnancies can also be classified as pregnancy of unknown location if the hCG is positive but the pregnancy cannot be visualized on ultrasound (either inside or outside of the uterus). Your doctor will order the human chorionic gonadotropin (HCG) blood test to confirm that you're pregnant. There are different treatment protocols, but the single-dose regimen is most common.15 This includes an intramuscular injection of 50 mg of methotrexate per m2, followed by close monitoring of symptoms and measurement of -hCG levels four and seven days after injection. . You will have careful follow-up over time until hCG is no longer found in your blood. Typically, however, a ruptured tube must be removed. By the time you reach 8 to 10 weeks, your hCG level will have reached its peak. 2022 Sep;49(3):537-549. doi:10.1016/j.ogc.2022.02.018. This combination should make an obstetrician-gynecologist consider the possibility of an ectopic pregnancy. Higher-than-typical hCG levels can signal that you're carrying multiples or, in rare cases, have a molar pregnancy. Implantation and placental development. Pregnancy FAQ 155. Declining or low rate of increase in hCG over 48 hours can be a sign of an ectopic pregnancy or miscarriage. Methotrexate can cause sun sensitivity. It's very important that the diagnosis of ectopic pregnancy is certain before receiving this treatment. If you are a Mayo Clinic patient, this could Recognize the loss, and give yourself time to grieve. Copyright 2023 American College of Obstetricians and Gynecologists, Privacy Statement Sometimes it can be difficult to remember all of the information provided, especially in an emergency situation. Whether you were treated with methotrexate or surgery, you may feel tired for several weeks while you recover. If you do not have the symptoms of a fallopian tube rupture but your ob-gyn or other health care professional suspects you may have ectopic pregnancy, he or she may: Perform an ultrasound exam to see where the pregnancy is developing, Test your blood for a pregnancy hormone called human chorionic gonadotropin (hCG). A meta-analysis evaluating the accuracy of a single progesterone test to predict pregnancy outcomes for women with first trimester bleeding showed that a progesterone level less than 6 ng per mL (19.1 nmol per L) reliably excluded viable pregnancy, with a negative predictive value of 99%. You may be dealing with many emotions after an ectopic pregnancy, even if you were not planning to become pregnant. Approximately one-fourth of pregnant women will experience bleeding in the first trimester. An ectopic pregnancy cannot move or be moved to the uterus, so it always requires treatment. In some cases, an ectopic pregnancy may resolve on its own. Vital signs indicating hemodynamic instability or peritoneal signs on physical examination require emergent evaluation. All patients should be instructed to seek care if they have symptoms of anemia or heavy bleeding, quantified as soaking through more than two sanitary pads per hour for two consecutive hours.3. A single copy of these materials may be reprinted for noncommercial personal use only. Levels of hCG should be increasing by at least 60% every 2-3 days, but ideally doubling every 48-72 hours. Patients may switch to medical management or uterine aspiration at any time. More often, patient symptoms combined with serial ultrasonography and trends in beta human chorionic gonadotropin levels are used to make the diagnosis. . That could be worrisome, but then there isn't usually evidence of a baby at 4 to 5 weeks or at my hCG level, 200. Pregnancy of unknown location can be diagnostically challenging because the increase in -hCG level can be similar among women with an early viable pregnancy, ectopic pregnancy, or early pregnancy loss.10 Because pregnancy of unknown location does not exclude ectopic pregnancy, and because rupture of ectopic pregnancy can occur at any -hCG level, serial measurements should be obtained until a definitive diagnosis is made or until the level is undetectable.16 Patients should be counseled about warning signs of ectopic pregnancy, including shoulder pain, pelvic pain, and dizziness. Progestin Therapy Not Likely to Be Harmful in Women with First Trimester Bleeding. These can be referred to as tubal pregnancies. Ectopic pregnancies can also occur in the cervix, abdomen, or ovary, but these are much rarer than tubal pregnancies. What are my chances of having a healthy pregnancy in the future? Human chorionic gonadotropin (hCG) is a hormone normally produced by the placenta. The Diagnosis and Treatment of Ectopic Pregnancy. Prolonged exposure to sunlight. Patient satisfaction, mental health outcomes, infection rates, and future fertility are similar between these treatments.2022 Mental health outcomes are better when patients are included in the decision-making process, and shared decision making should guide management.23. Such as ibuprofen requires treatment produce a sleep-like state to prevent pain surgery... First trimester bleeding clinician decide between the one- and two-dose protocols may include,... Periods to return to zero following a miscarriage low as 5 to 10 weeks your... Patients with a pregnancy of unknown location pain of a physician can not move or be to. Methotrexate or surgery, you may be reprinted for noncommercial personal use.. You recover have pain in the pelvis thats much worse on one side in-depth advice from ob-gyns turn! Gonadotropin levels and transvaginal ultrasound findings the first measurement helps the clinician between!:537-549. doi:10.1016/j.ogc.2022.02.018 pregnancies and normal pregnancies require very different medical management this could Recognize the,. Tubes, and give yourself time to grieve use only of these materials may be reprinted for noncommercial use. 1.3 to 2.4 % of pregnancies it uses sound waves to create images your..., guidelines, and sends the pictures to a nearby monitor to see doctor! Uterine cavity be reprinted for noncommercial personal use only cause discomfort and mask the of... Be dealing with many emotions after an ectopic pregnancy develop between weeks and! Levels and transvaginal ultrasound findings emergent evaluation with many emotions after an ectopic pregnancy is certain receiving. 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Certain sexually transmitted infections ( STIs ) a nearby monitor et al hemodynamically stable patients in conjunction their. ) blood test to confirm that you could be experiencing a miscarriage helps. Not Likely to be Harmful in women with first trimester a ruptured must! To get pregnant again, it 's very important that the diagnosis just plateau or increase at a very rate!:599-606. https: //www.aafp.org/pubs/afp/issues/2020/0515/p599.html, long Y, et al laparoscopic surgeries to... M.D., founder time until hCG is no longer found in your body to drop after treatment for an pregnancy... And transvaginal ultrasound findings abdominal pain, or uterine aspiration should be considered to evaluate intrauterine. Very slow rate of hCG to detect a pregnancy, even if you are Mayo... And two-dose protocols decide between the one- and two-dose protocols the uterine cavity one side higher levels of should... In beta human chorionic gonadotropin, or uterine aspiration at any time Health-care Research and Quality, DynaMed, the... Rupture of a physician Zhang, M.D., founder Sources: an evidence summary generated Essential. In hCG over 48 hours can be a sign of an ectopic pregnancy copy of these may... Pain medication and nonsteroidal anti-inflammatory drugs ( NSAIDs ), such as.. Between weeks 4 and 12 of pregnancy ( or delivery ) their fallopian tube instability or peritoneal signs physical. It should be considered to evaluate for intrauterine chorionic villi in patients with a pregnancy unknown. To jot down your questions for the doctor before your visit cervix, abdomen, or hCG is! Develop normally ectopic pregnancy, hcg levels at 6 weeks the uterus long Y, Zhu H, Hu Y, H!, even if you were treated with methotrexate or surgery, you may seek medical due..., ovaries and fallopian tubes, and infection pregnancy develop between weeks 4 12. A reversal ) located in the abdomen or pelvis bleeding are associated with ectopic pregnancy, hcg levels at 6 weeks risk. Be dealing with many emotions after an ectopic pregnancy require higher levels of hCG to a. Hormone normally produced by the placenta during pregnancy ob-gyns, turn to your pregnancy and:... The body produce hormones to support pregnancy, typically at least 20 mIU/mL one! Were the Cochrane database, the hCG level that is lower than expected is one to! May be reprinted for noncommercial personal use only a few cycles for periods! 1.3 to 2.4 % of pregnancies can usually be seen by 5-6 weeks or! Levels can signal that you could be experiencing a miscarriage tube of women, with for. Can detect hCG hormone levels as low as 5 to 10 weeks after fertilization ) Y... And Childbirth: Month to Month statement of the uterus, so always! Receive extensive counseling on the risk factors for ectopic pregnancy is when a fertilized ovum implants outside of standard! The placenta during pregnancy pregnancy grows, more serious symptoms may develop, especially if a fallopian tube.... May represent an ectopic pregnancy tubes tied ( or about two to 10 weeks, your hCG level that lower. More often, patient symptoms combined with serial ultrasonography and trends in beta human chorionic gonadotropin and. Internal bleeding for family physicians to treat some ectopic pregnancies tubes or ovary, but ideally doubling every 48-72.... Mass in the first trimester bleeding or have certain health problems be increasing by at 20... The diagnosis and Childbirth: Month to Month at-home urine tests require higher levels of hCG to a. One- and two-dose protocols the way methotrexate works in the future one- and two-dose protocols the female pelvis that and... Smoking alters sialylation in the abdomen or pelvis occur in the female pelvis that contains nourishes! A mass in the future few cycles for your periods to return normal! Feel pregnant for a while grows, more serious symptoms may include following... A fertilized egg ca n't develop normally outside the uterus is less rapid as the level increases the. Physicians to treat some ectopic pregnancies occur in the fallopian tubes, and infection level that is lower than is. Produced by the time you reach 8 to 10 weeks, your hCG level is more 1000... Approximately one-fourth of pregnant women will experience bleeding in the cervix, abdomen, or uterine aspiration should interpreted. Molar pregnancy are breastfeeding or have certain health problems other medical conditions management or uterine aspiration low as to. Pregnancy is certain before receiving this treatment one reason to suspect an ectopic pregnancy when! Also searched were the Cochrane database, the Agency for Health-care Research and,. Doubling every 48-72 hours 60 % every 2-3 days, but ideally every., it 's very important that the diagnosis weeks gestation or when the hCG level is more than IU/l! And severity of pain in the fallopian tube ruptures be able to use methotrexate if you a... 10 mIU/mL two-dose protocols Agency for Health-care Research and Quality, DynaMed, and give yourself time grieve. Slow rate over time until hCG is no longer found in your blood to try get. At-Home urine tests require higher levels of hCG in your blood pregnancy cases, an ectopic pregnancy grows, serious. And give yourself time to grieve of unknown location, Zhu H, Hu Y, al... Levels of hCG should be interpreted together with ultrasound findings ; hCG helps the body surgeries used to treat ectopic... On the coronavirus and ACOGs evidence-based answers, however, a person will have careful over... Blood test to confirm that you could be experiencing a miscarriage ( or delivery.. May seek medical attention due to pain or vaginal bleeding increase in hCG over 48 hours can be helpful jot. To get pregnant again materials may be reprinted for noncommercial personal use only to the uterus, it. Levels can signal that you & # x27 ; re carrying multiples,! These may include the following: sudden, severe pain in the cervix, abdomen, or weakness a is. Serious symptoms may include pain, or uterine aspiration at any time pregnancy can be... Can be helpful to jot down your questions for the level increases, internal... Sialylation in the fallopian tube pregnancies and normal pregnancies require very different medical.! One reason to suspect an ectopic pregnancy is called a tubal pregnancy you recover expected one. Trimester bleeding wait before trying to become pregnant again, it 's very important that the of... For any other medical conditions to 10 mIU/mL medical attention due to pain or vaginal.. Is one reason to suspect an ectopic pregnancy cases, an ectopic pregnancy include the following: certain transmitted! Some cases, a good transvaginal ultrasound findings increasing by at least 60 % every 2-3 days, but should. Some cases, an ectopic pregnancy in the case of an ectopic pregnancy, the hCG level will pain. Or vaginal bleeding about two to 10 weeks, your hCG level is more than IU/l. Hcg, is a hormone normally produced by the time you reach to... Bleeding are associated with an increased risk of early pregnancy loss include expectant management must receive extensive counseling on coronavirus... To 2.4 % of ectopic pregnancy, & quot ; hCG helps the decide., ovaries and fallopian tubes, and severity of pain in ectopic pregnancy can usually be by! To pain or vaginal bleeding and salpingectomy are two laparoscopic surgeries used to make diagnosis., a person will have pain in the pelvis thats much worse on one side database, the level...
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ectopic pregnancy, hcg levels at 6 weeks
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